![]() ![]() Mechanism of action: Hydrocodone acts primarily as an agonist at the mu-opioid receptors, but is also a weak agonist against the delta opioid and kappa opioid receptors.Laboratory function tests should be used to monitor therapy in people with severe liver or renal disease. Ĭoncurrent use of paracetamol with alcohol products may increase the risk of acute liver failure. Hydrocodone may demonstrate an enhanced respiratory depressant effect when combined with other sedatives such as other opioids, benzodiazepines, nonbenzodiazepine sedatives, psychotropics, and anticonvulsants. Paracetamol: Liver and kidney failure, low blood sugar coma may occur. Hydrocodone: Respiratory depression, extreme somnolence progressing towards coma, muscle limpness, cold and clammy skin, slow heart rate, low blood pressure, abrupt loss of heart function, and death may occur. Most of the cases of liver injury are associated with the use of paracetamol at doses that exceed 4000 milligrams per day, and often involve more than one paracetamol-containing product." Overdose "Paracetamol has been associated with cases of acute liver failure, at times resulting in liver transplant or death. Hearing impairment, permanent hearing loss. ![]()
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