![]() ![]() The impairment in selecting 17.5☌ resulted from absence of an avoidance response, which is normally mediated by an increase in turns at the lower temperatures. Mutations affecting a transient receptor potential (TRP) vanilloid channel, Inactive (Iav), which is expressed specifically in chordotonal neurons, eliminated the ability to choose 17.5☌ over 14☌-16☌. This study demonstrates that Drosophila larvae choose their preferred temperature of 17.5☌ over slightly cooler temperatures (14-16☌) through activation of chordotonal neurons. This behavior is critical as small differences in temperature of only several degrees can have a profound effect on the survival and rate of development of poikilothermic animals, such as the fruit fly. Mutant defects in sperm competition suggest that both dyneins also function in sperm motility.Īnimals select their optimal environmental temperature, even when faced with alternatives that differ only slightly. Dmdnai2, in addition to being required for amplification, is essential for outer dynein arms in auditory neuron cilia. Epistasis analysis revealed that Dmdnah3 acts downstream of Nan- Iav channels in controlling the amplificatory gain. Null alleles of both dyneins equally abolished electrical auditory neuron responses, yet whereas mutations in Dmdnah3 facilitated mechanical amplification, amplification was abolished by mutations in Dmdnai2. ![]() Promoter fusions revealed that the two axonemal dynein genes Dmdnah3 (=CG17150) and Dmdnai2 (=CG6053) are expressed in chordotonal neurons, including the auditory ones in the fly's ear. This study describes two axonemal dynein proteins that are required for Drosophila auditory neuron function, localize to their primary cilia, and differently contribute to mechanical amplification in hearing. Because the neurons bear mechanosensory primary cilia whose microtubule axonemes display dynein arms, it was hypothesized that their motility is powered by dyneins. Much like vertebrate hair cells, the chordotonal sensory neurons that mediate hearing in Drosophila are motile and amplify the mechanical input of the ear. Diverse roles of axonemal dyneins in Drosophila auditory neuron function and mechanical amplification in hearing. S., Kittelmann, M., Spalthoff, C., Katana, R., Sivan-Loukianova, E., Schon, M. Genetic map position - chrX:6708151-6712189Ĭlassification - ankyrin repeats protein, Transient Receptor Potential Ca2+ Channel (TRP-CC) FamilyĬellular location - surface transmembrane Keywords - channel, thermosensory behavior, peripheral nervous system, hearing, antenna Function - Transient Receptor Potential Ca2+ Channel ![]()
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